Identification of hub anoikis-associated genes and risk signature in...
OBJECTIVE: As one of the most lethal and aggressive cutaneous malignancies, cutaneous melanoma (CM) greatly threatens human health and has long challenged clinicians because of its poor therapeutic...
View ArticleThe identification of sex-specific biomarkers in peripheral blood mononuclear...
OBJECTIVE: The aim of this study was to identify sex-specific biomarkers for ischemic stroke (IS) prophylaxis in elderly individuals. MATERIALS AND METHODS: The GSE22255 dataset for elderly individuals...
View ArticleBioinformatics analysis of wild-type ParC and S79F, S79Y mutations in...
OBJECTIVE: S79Y and S79F mutations in ParC at the fluoroquinolone binding site confer resistance to quinolones in Streptococcus pneumoniae. The aim of this study was to perform bioinformatics analysis...
View ArticleA comprehensive analysis of nucleotide excision repair characteristics...
OBJECTIVE: Nucleotide excision repair (NER) has been associated with various types of malignant tumors. However, the precise roles of nucleotide excision repair-related genes (NERGs) in acute myeloid...
View ArticleDevelopment and validation of biomarkers related to PANoptosis in osteoarthritis
OBJECTIVE: Osteoarthritis (OA) is a high-incidence disease of the orthopedic system. However, studies on the molecular mechanisms of OA and pyroptosis, apoptosis, and necroptosis (PANoptosis) at the...
View ArticleBioinformatics screening of gene expression profile and diagnostic...
OBJECTIVE: The aim of this study was to research gene expression profiles and diagnostic applications of meningeal carcinoma based on bioinformatics. MATERIALS AND METHODS: We used the Gene Expression...
View ArticleMolecular docking technology and network pharmacology based on Rhapontici...
OBJECTIVE: Network pharmacology is a bioinformatics-based research strategy for identifying the mechanisms of drugs and promoting drug development. This study used network pharmacology to investigate...
View ArticleMAGI-Dock: a PyMOL companion to Autodock Vina
Molecular docking simulation of small molecule drugs to macromolecules is valuable in structural biology and medicinal chemistry research. Its spread is supported by freely available software and...
View ArticleUnleashing the potential of biotechnology for sustainable development
The UN Sustainable Development Goals (SDGs) strive to eliminate poverty, preserve the planet, and promote shared prosperity through sustainable and inclusive means by 2030. This requires the...
View ArticleBioinformatic analysis identified common pathogenetic processes between...
OBJECTIVE: With the ongoing progression of SARS-CoV-2-induced COVID-19, the post-acute COVID-19 syndrome (long COVID) has garnered increasing attention as a novel multisystem disorder. Long COVID-19...
View ArticlePrognostic and immune roles of UROC1 in human cancers: from mechanism...
OBJECTIVE: Both non-alcoholic fatty liver disease (NAFLD) and hepatocellular carcinoma (HCC) are prevalent diseases worldwide. This study aimed to explore the underlying mechanisms of NAFLD and HCC and...
View ArticleDevelopment of a clinical prediction model for diabetic kidney disease with...
OBJECTIVE: In this study, we investigated the internal relationship between the pathogenesis of diabetic kidney disease (DKD) and abnormal glucose and lipid metabolism to identify potential biomarkers...
View ArticleIdentifying critical genes and pathways of doxorubicin-induced cardiomyopathy...
OBJECTIVE: The pathogenesis of doxorubicin (DOX) induced cardiomyopathy (DCM) is still uncertain. We aimed to identify the critical genes and pathways involved in DCM based on bioinformatics analysis....
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